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Results: 3
Reassessment of weak parent-of-origin expression bias shows it rarely exists outside of known imprinted regions.
Carol A Edwards, William MD Watkinson, Stephanie B Telerman, Lisa C Hulsmann, Russell S Hamilton, Anne C Ferguson-Smith
Apr 12, 2023
C4 gene induction during de-etiolation evolved through changes in cis to allow integration with ancestral C3 gene regulatory networks.
Pallavi Singh, Sean R Stevenson, Patrick J Dickinson, Ivan Reyna-Llorens, Anoop Tripathi, Gregory Reeves, Tina B Schreier, Julian M Hibberd
Apr 17, 2023
C4 photosynthesis has evolved by repurposing enzymes found in C3 plants. Compared with the ancestral C3 state, accumulation of C4 cycle proteins is enhanced. We used de-etiolation of C4 Gynandropsis gynandra and C3 Arabidopsis...
Multi-ancestry phenome-wide association of complement component 4 variation with psychiatric and brain phenotypes in youth.
Leanna M Hernandez, Minsoo Kim, Pan Zhang, Richard A I Bethlehem, Gil Hoftman, Robert Loughnan, Diana Smith, Susan Y Bookheimer, Chun Chieh Fan, Carrie E Bearden, Wesley K Thompson, Michael J Gandal
Apr 07, 2023
Background
Increased expression of the complement component 4A (C4A) gene is associated with a greater lifetime risk of schizophrenia. In the brain, C4A is involved in synaptic pruning; yet, it remains unclear the extent...
Brain complement Genetics Schizophrenia Gene Expression Psychosis Neuroimaging Humans Cognition Mental Disorders Phenotype Complement C4
Published by: Genome biology